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August 13, 2021

International Overdose Awareness Day: August 31



Overdose can happen to anyoneEvery August 31, the International Overdose Awareness Day campaign works to end overdose, reduce stigma of drug-related death, and acknowledge the grief of family and friends left behind from those who have died. This year's theme is "Time to Remember. Time to Act" and the campaign is using #EndOverdose on social media.

Make sure to check out:

National Recovery Month: September 1-30

Recovery Month 2021Recovery Month is a national observance held every September to educate Americans that substance use treatment and mental health services can enable those with a mental and/or substance use disorder to live a healthy and rewarding life.

The 2021 National Recovery Month theme, "Recovery is For Everyone: Every Person, Every Family, Every Community," reminds people in recovery and those who support them that no one is alone in the journey through recovery.

Find events, share stories and photos, and download resources here.

CTN Trial Progress

GraphRandomizations for Active Studies as of the August 12 trial Progress Report.

CTN-0060-A-1 - Enrolled 644

CTN-0079-A-1 - Enrolled 33   

CTN-0080 - Enrolled 60

CTN-0082 - Enrolled 559

CTN-0097 - Enrolled 128

CTN-0099 - Enrolled 515

CTN-0099-A-1 - Enrolled 81

Discontinuation - Enrolled 10
Retention - Enrolled 44

CTN-0101 - Enrolled 44

This project is supported by a grant from the National Institute on Drug Abuse to the University of Washington Alcohol and Drug Abuse Institute, but the information on this site has not been reviewed by NIDA and does not necessarily reflect the views of the Institute.

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New in the CTN Dissemination Library

High-Dose Buprenorphine Induction in the Emergency Department for Treatment of Opioid Use Disorder. Herring AA, et al. JAMA Network Open 2021; 4(7):e2117128. CTN-0069-A-1 outcomes paper

Validating the Clinical Relevance of Alternative Stimulant Use Treatment Outcome Measures by Examining Their Association with 3-Month Follow-Up Outcomes. Miguel AQC, et al. Experimental and Clinical Psychopharmacology 2021;29(3):288-293. CTN-0006

Polysubstance Use, Mood Disorders, and Chronic Conditions with Anxiety in Opioid Patients. Liu S, et al. Western Journal of Nursing Research 2021 (in press). CTN-0027

Prevalence of Medical Cannabis Use and Associated Health Conditions Documented in Electronic Health Records Among Primary Care Patients in Washington State. Matson TE, et al. JAMA Network Open 2021;4(5):e219375. CTN-0077-Ot

Factors Associated with Healthcare Effectiveness Data and Information Set (HEDIS) Alcohol and Other Drug Measure Performance in 2014-2015. Weisner C, et al. Substance Abuse 2019;40(3):318-327. CTN-0072-Ot

Sublingual Buprenorphine-Naloxone Compared with Injection Naltrexone for Opioid Use Disorder: Potential Utility of Patient Characteristics in Guiding Choice of Treatment. Nunes EV, et al. American Journal of Psychiatry 2021;178:660-671. CTN-0051

Gender Differences in the Associations of Multiple Psychiatric and Chronic Conditions with Major Depressive Disorder Among Patients with Opioid Use Disorder. Nwabueze C, et al. Journal of Addictive Diseases 2021 (in press). CTN-0027

Engagement Patterns with a Digital Therapeutic for Substance Use Disorders: Correlations with Abstinence Outcomes. Luderer HF, et al. Journal of Substance Abuse Treatment 2021 (in press). CTN-0044

Racial/Ethnic Equity in Substance Use Treatment Research: The Way Forward [commentary]. Burlew AK, et al. Addiction Science & Clinical Practice 2021;16:50.

Concomitant Cannabis Misuse and Associations with Depression, Pain and Substance Misuse Among Patients Prescribed Opioids. Bryan MA, et al. Pharmacy 2021;9:134. CTN-0093

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News from the Nodes

New England Consortium

Yales News logoGail D’Onofrio, one of the PIs of the New England Consortium Node, was recently featured in an article in Yale News about the new outcomes paper from CTN-0069-A-1.

The study found that administration of high-dose buprenorphine therapy in hospital emergency departments (ED) may safely and rapidly diminish withdrawal symptoms and sustain craving suppression in people with opioid use disorder, improving their likelihood of accessing follow-up treatment.

In the Yale News piece, Dr. D’Onofrio says, "The study enhances the evidence we know about ED buprenorphine disorder, and could be a game changer, particularly for vulnerable populations."

Find the Yale News article here | Find the outcomes article here


Dr. Mary Brunette named Mental Health Professional of the YearMary Brunette

Northeast Node Core Investigator Mary Brunette, MD, was recently named the Mental Health Professional of the Year by the New Hampshire chapter of the National Alliance on Mental Illness (NAMI).

Dr. Brunette’s work focuses on severe mental illness (SMI), particularly with first episode psychosis and early onset SMI, and co-occurring substance use disorders.

Dr. Brunette is a Professor of Psychiatry, Community & Family Medicine, and The Dartmouth Institute for Health Policy and Clinical Practice at the Geisel School of Medicine at Dartmouth College, and Medical Director of the Bureau of Behavioral Health in the New Hampshire Department of Health and Human Services.

You can read an article here about Dr. Brunette’s award.

Center for Technology and Behavioral Health at Geisel School of Medicine, Dartmouth seeking 2 Postdoc Research Fellows

The parent organization of the Northeast Node, the Center for Technology and Behavioral Health (CTBH) at the Geisel School of Medicine at Dartmouth College, is accepting applications for two Postdoctoral Research Fellows to join a dynamic interdisciplinary research group.

  • Position One will involve joining a team focused on identifying optimal models of substance use treatment and health care for pregnant and parenting women with opioid use disorder and their children.
  • The focus of Position Two is open and would involve working with one or more teams led by CTBH faculty located at Dartmouth.

The Research Fellows will also become immersed in our innovative T32 training program focused on the Science of Co-Occurring Disorders and funded by the National Institute on Drug Abuse. The program offers predoctoral and postdoctoral training in transdisciplinary and translational research on co-occurring substance use and other health conditions. Multidisciplinary faculty offer training in developmental, social, behavioral, neurobiological, and transdiagnostic mechanisms of substance use, mental health, and co-occurring disorders.

We are committed to promoting equity and inclusion in our research and central to this mission is a commitment to fostering research training for historically underserved trainees.

For more information on these two opportunities: https://www.c4tbh.org/employment-opportunities/


Southwest NodeThe Southwest Node recently offered two sessions of Harm Reduction and Pharmacotherapy Training for Health Professionals, delivered by Erin Madden, PhD, MPH, Faculty at Wayne State University, and Mindy Vincent, MSW, LCSW, MPA, Executive Director, Utah Harm Reduction Coalition.

The training was attended by clinicians, researchers, social workers, and policy workers around New Mexico. The training introduced participants to the principles of harm reduction and addressing stigma, and explored how harm reduction and treatment can complement each other, and discussed stigma around interventions for people who inject drugs and people who use opioids.

A follow-up training is in development to dive deeper into complex concepts about stigma and how providers, healthcare staff, and policy makers can reduce stigma around pharmacotherapy through advancing knowledge and action. If you would like to receive communications about future training opportunities, please email SouthwestCTN@salud.unm.edu.



Pacific Northwest

ADAI logoDr. Mary Hatch-Maillette’s team at the University of Washington’s Addictions, Drug & Alcohol Institute (ADAI) participated in the 2021 NIDA Summer Research Internship Program. Intern Gaia Norman, a rising junior at George Washington University, joined ADAI and the CTN-0082 lead team for 6 weeks.

She spent 1 week in Seattle visiting face-to-face with CTPs and Node investigators and 5 weeks working virtually from her home in San Diego. In addition to her substantive contributions, she wrote a tongue-in-cheek summary of her internship experience. Enjoy an excerpt below!

All I’ve Learned!

It’s been a fantastic summer, so there’s much to say.
I honestly can’t thank you enough.
CTN0082 PROCESS survey
really did teach me a whole bunch of stuff.

I gained a clear sense of how research operates:
A multitude of moving pieces.
Like what you do when sites don’t cooperate
or you aren’t seeing enough recruitment increases.

I saw what protocol deviations might look like
and what a headache it can be.
That you must, when doing research in psych,
dot every "I," cross every "T," ... and report to every IRB.

Always protect your human subjects and update your SOPs
because research values ethics and precision.
Better to communicate your moves and check in with the team
and remember that writing takes constant revision.

Confidential is not the same as anonymous,
and randomization is not a suggestion.
If Zoom working starts to feel monotonous,
eat a snack to spur your digestion.

You all work with people much more than I thought:
sites, EMMES, NIDA, and the folks I can’t remember.
The kindness in your hearts impressed me a lot.
I was genuinely honored to be considered your team member.

You welcomed me in a manner that was incredibly sweet
despite working from home being a bit of a bummer.
Seeing strong female leadership was such a treat
and made for quite a valuable summer.

~Gaia Norman, NIDA Summer Intern 2021

Western States

LEAD Holds 4-week Intensive Training for Emerging Investigators

Western States NodeFrom June 28 -July 23, 2021 the Learning for Early Careers in Addiction & Diversity (LEAD) program held its 7th annual intensive training for emerging researchers in drug use clinical trials.

The nine LEAD scholars accumulate background in research and grant-writing methods. Participants also plan and conduct pilot studies that can result in competitive independent research grant proposals. Scholars from underrepresented populations join the program, participating for 3 years in intensive summer training and all-year mentorship by successful investigators, many of whom are part of research nodes in the NIDA Clinical Trials Network (CTN).

LEAD is funded by a NIDA/NIH science education grant and is associated with the CTN Western States Node (WSN). In the last seven years LEAD has worked with 20 Scholars, none of whom had previously led a NIH research grant. 12 Scholars have now succeeded in becoming NIH Principal Investigators.

We note that Martin Iguchi, recently deceased, was a terrific advisor to LEAD, its mentees, and its CTN research node, and he provides a lasting role model for the program’s contributors.

The LEAD Scholars in this summer’s training, and their mentors are listed below (click graphic to view full size):


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Protocol Updates

It has been a busy time for CTN-0062-Ot, which is wrapping up this year. This study examines the feasibility and process of implementing EHR-integrated screening for substance use as part of routine primary care visits. Screening tools, paired with clinical decision support, were implemented in 6 clinics (from 2 health systems), resulting in over 65,000 patients (72% of all patients) completing screening for alcohol and drug use.

The primary manuscript, presenting implementation outcomes for the parent study was published in JAMA Network Open. Data extracts from the electronic health records of all participating sites, which will provide additional detail about screening processes and outcomes, are now being analyzed.

For dissemination, the Lead Team is working with the Bizzell Group and Simmersion, LLC. to create an interactive online tool that will guide clinic staff through the process of implementing screening in primary care settings. The online tool is scheduled to go live later in 2021.


Data Collected!

CTN Lead Team Partners, in the Greater New York Node and the Pacific Northwest Node, are happy to announce that CTN-0082: Implementation Survey of PrEP and Opioid Use Related Services in STI Clinics and Community Based Organizations (CBOs) (PROCESS Survey) has finished data collection! In 13 community STI clinics and harm reduction/substance use treatment programs in eight higher HIV incidence Southeast cities, N=559 clients and N=210 providers completed surveys, and N=13 directors completed qualitative interviews.

The Lead Investigators would like to give a big shout out to the amazing Site Champions and Site Coordinators, National Project Directors, Local Node Collaborators at the Southern Consortium and Florida Alliance Nodes, CCTN, and EMMES CCC and DSC Collaborators for their extraordinary proficiency, commitment, and humanity in carrying this study forward during these difficult pandemic times.

CTN-0082 Received AHSR 2021 "Top-Rated Abstract" Recognition

CTN Lead Team Partners, in the Greater New York Node and the Pacific Northwest Node, are excited that an abstract submitted to the AHSR Virtual Conference 2021, "Pandemic-prompted telehealth: A snapshot of its use in community programs serving people who use substances at high risk for HIV," was selected as a "Top-Rated Abstract." Dr. Hatch-Maillette will join others in this category to give a lightening talk about the use of telehealth service delivery in SSPs, STI clinics, and SUD treatment programs during the pandemic. Data are based on an ancillary survey of participating sites in CTN-0082.

The Lead Investigators would like to thank the Site Champions and Site Coordinators, National Project Directors, Local Node Collaborators at the Southern Consortium and Florida Alliance Nodes, CCTN, and EMMES CCC and DSC teams for their outstanding contributions to the success of this protocol.

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Upcoming Events

  • National Latino Behavioral Health Conference
    September 16-27, 2021 | Meeting info

  • Addiction Health Services Research (AHSR) 2021
    October 13-15, 2021 | Meeting info

  • American Public Health Association (APHA)
    October 23-27, 2021 | Meeting info



New from the ATTC & SAMHSA


Published by the CTN Dissemination Library of the Pacific Northwest Node
Addictions, Drug & Alcohol Institute, University of Washington

This project is supported by a grant from the National Institute on Drug Abuse to the University of Washington Addictions, Drug & Alcohol Institute, but the information on this site has not been reviewed by NIDA and does not necessarily reflect the views of the Institute.

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