CTN Trial Progress

Randomizations for Active Studies as of the November 10 Trial Progress Report.

CTN-0080 - Enrolled 111

CTN-0097 - Enrolled 415

CTN-0098 - Enrolled 94

CTN-0099 - Enrolled 1234

CTN-0099-A-1 - Enrolled 92

CTN-0100
Discontinuation - Enrolled 93
Retention - Enrolled 567

CTN-0101 - Enrolled 188

CTN-0107 - Enrolled 88

CTN-0108 - Enrolled 60

New Protocol: CTN-0107-A

CTN-0107-A-1 has been funded as an add-on to CTN-0107, led by Angie Moreland PhD and Lindsey Jennings MD, MPH of the Southern Consortium Node.

The objectives of this study include understanding the strengths and weaknesses of embedding peer support specialists into the emergency department, provider-level barriers to the CTN-0107 program and peer support specialist activities, effective strategies to increase Emergency Department-initiated buprenorphine (EDIB) acceptance, reasons and barriers to acceptance of EDIB, ways to improve EDIB uptake, and social determinants of health.

This knowledge is imperative to public health efforts addressing the opioid epidemic, as results can be used to improve harm reduction interventions by addressing critical gaps for ED patients with OUD. We will accomplish this objective by conducting semi-structured interviews with peer support specialists, emergency medicine practitioners, and patients who either accept or decline buprenorphine in the emergency department. We will also gather information on acceptability, feasibility, and appropriateness of EDIB; and social determinants of health.

New from the ATTC Network

Virtual Training More Cost-Effective Than In-Person Training for Contingency Management. Northwest ATTC. ATTC Messenger, November 2022

SAMHSA Resource: Tips for Disaster Responders: Understanding Historical Trauma and Resilience When Responding to an Event in Indian Country

Embracing Change: Providing Program Specific Harm Reduction Technical Assistance. Lisa Carter & Jill Eriksen (Mid-Atlantic ATTC) and Katie Burk, Facente Counseling. ATTC/NIATx Service Improvement Blog.

Embracing Change: Audio-Only Telehealth: Expanding SUD Treatment/Recovery Services. Nancy Roget, Cindy Juntunen, Trisha Dudkowski (Mt. Plains ATTC). ATTC/NIATx Service Improvement Blog

New in the CTN Dissemination Library

Primary Outcomes for CTN-0111:
Machine Learning Techniques to Explore Clinical Presentations of COVID-19 Disease Severity and to Test the Association with Unhealthy Opioid Use (UOU): Retrospective Cross-Sectional Cohort Study. Thompson HM, et al. JMIR Public Health and Surveillance 2022 (in press).

The Association Between Buprenorphine Treatment Duration and Mortality: A Multi-Site Cohort Study of People Who Discontinued Treatment. Glanz JM et al. Addiction 2022 (in press). CTN-0084-A-1

National Institute on Drug Abuse: Dissemination of Scientific Knowledge to Improve Adolescent Health. Subramaniam GA, et al. Child and Adolescent Psychiatric Clinics of North America 2022 (in press).

Patient Perspectives on Opioid Risk Discussions in Primary Care. Hooker SA, et al. Journal of Patient-Centered Research and Reviews 2022;9(4):253-262. CTN-0095

Validity of the Single-Item Screen-Cannabis (SIS-C) for Cannabis Use Disorder Screening in Routine Care. Matson TE, et al. JAMA Network Open 2022;5(11):e2239772.

Development and Testing of Data Infrastructure in the American College of Emergency Physicians' Clinical Emergency Data Registry for Opioid-Related Research. Taylor A, et al. JACEP Open 2022;3(5):e12816. CTN-0081

Risky Alcohol Use Among Patients Dispensed Opioid Medications: A Clinical Community Pharmacy Study. Cochran G, et al. Drug & Alcohol Dependence 2022;234:109406. CTN-0093

Analysis of Health Trajectories Leading to Adverse Opioid-Related Events. Gilson AS, et al. AMIA Joint Summits on Translational Science 2021;248-256. CTN-0099

Centering Culture in the Treatment of Opioid Use Disorder with American Indian and Alaska Native Communities: Contributions from a National Collaborative Board. Hirchak KA, et al. American Journal of Community Psychology 2022 (in press). CTN-0096

News from NIDA

Video Gaming May Be Associated with Better Cognitive Performance in Children

This news release from NIDA reports on a recent study of nearly 2,000 children that found that those who reported playing video games for 3 hours per day or more performed better on cognitive skills tests involving impulse control and working memory compared to children who had never played.

Read more about the study here.

Upcoming National Events

Human Subjects Research: Policies, Clinical Trials, and Inclusion
December 6-7, 2022 (virtual).
What are the basic HHS regulations and NIH policies that apply to involving human subjects? How do you prepare a research proposal for review addressing those requirements?

15th Annual Conference on the Science of Dissemination and Implementation in Health
December 11-14, 2022 (Washington DC)
Theme: (Re)Building Better Systems: Being Proactive, Nimble, and Responsive.