CTN-0150: Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME) for pregnant and postpartum persons in MOUD
T. John Winhusen, PhD
Principal Investigator
University of Cincinnati
winhust@ucmail.uc.edu
Opioid-related overdoses in pregnant and postpartum (PP) persons have risen dramatically during the last few years. CTN-0150 has two objectives: 1) To evaluate the ability of the Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME) intervention to increase MOUD and opioid-overdose knowledge in PP persons (primary); 2) To evaluate the ability of TOME to decrease MOUD-related internalized stigma and expected difficulty in avoiding drug use.
Primary Findings
In a sample of peripartum patients enrolled in MOUD for a substantial length of time, TOME significantly increased MOUD and opioid overdose (OOD) knowledge. Taken together with past research, these findings suggest that there are gaps in MOUD and OOD knowledge in individuals with opioid use disorder that can be addressed with brief personally-tailored education.
Primary outcomes article: Winhusen TJ, et al. Personally-Tailored Opioid-Overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) Significantly Increases MOUD and Overdose Knowledge in Peripartum Individuals: Results from a Randomized Controlled Pilot Trial. Drug and Alcohol Dependence 2025;275:112795.
Related Resources
Node Involvement
Lead Node(s):