CTN-0125: Integrative Data Analysis of CTN Studies to Examine the Impact of Psychosocial Treatments for Black People who use Cocaine
Kathy Burlew, PhD
Co-Lead Investigator
University of Cincinnati
kathy.burlew@uc.edu
Lesia Ruglass, PhD
Co-Lead Investigator
City College of New York
lruglass@ccny.cuny.edu
The acceleration of opioid-involved overdose deaths among Black people is at least partly attributable to the presence of synthetic opioids (fentanyl) in the cocaine supply in approximately one third of opioid overdose deaths. The CTN provides a unique but underexplored collection of studies that can improve our knowledge on effective psychosocial treatments for Black people who use cocaine. The proposed study will combine data from 7 CTN treatment studies (total N = 1442 Black participants) that in combination present mixed findings. Using multiple emerging measurement/data analysis frameworks (integrative data analysis (IDA), meta-analysis of individual patient data (MIPD), and causal moderation analysis), the goal of the proposed study is to evaluate the effectiveness of substance use disorder treatments for Black people who use cocaine.
Primary Findings
Nine randomized controlled trials met inclusion criteria, with a combined sample of 1,381 Black adults who used cocaine and/or opioids. The inverse probability of treatment-weighted (IPTW) linear mixed models indicated that cocaine use severity decreased from baseline to end-of-treatment across three treatment groups, with a greater decrease for social-contextual treatments and contingency management (CM) compared to treatment-as-usual (TAU)/controls. This greater reduction was maintained at 12-month follow-ups for social-contextual treatments, but CM worsened relative to TAU/controls. Decreases in latent opioid use severity were found with no or minor differences between treatment groups.
Primary Outcomes Article: Burlew AK, et al. An Individual-Level Data Synthesis of Clinical Trials Network Studies to Examine the Impact of Psychosocial Treatments for Black People Who Use Cocaine and/or Opioids. Drug and Alcohol Dependence 2025;276:112850.
Related Resources
Node Involvement
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