CTN-0154: EMS Initiated Buprenorphine for Opioid Use Disorder
Gail D’Onofrio, MD, MS
Co-Lead Investigator
Yale University School of Medicine
gail.donofrio@yale.edu
Andrew Herring, MD
Co-Lead Investigator
Highland Hospital-Alameda Health System
aherring@alamedahealthsystem.org
Gerard Carroll, MD, FAAEM, EMT-P
Co-Lead Investigator
Cooper Medical School of Rowan University
carroll-gerard@cooperhealth.edu
Emergency Medical Services (EMS) encounters for opioid overdose and withdrawal offer a crucial touchpoint to initiate buprenorphine treatment and to increase treatment participation rates for persons with opioid use disorder (OUD). This project will develop and refine a prehospital EMS clinical field protocol to initiate buprenorphine in persons with OUD presenting with an overdose requiring naloxone rescue or acute opioid withdrawal. Employing a Delphi Consensus process and stakeholder focus groups; followed by a sequence of pragmatic controlled field studies, the study will provide preliminary feasibility, acceptability, and safety data. Finally, a multi-site, systematic, prospective evaluation trial will be conducted to assess the rates of engagement in continuation of medication for OUD post EMS initiation.
Funded by the NIH HEAL Initiative℠
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