How practice and science are balanced and blended in the NIDA Clinical Trials Network: The bidirectional process in the development of the STAGE-12 protocol as an example.

Bidirectional, collaborative partnerships between academic researchers and practitioners have been a fundamental vehicle to achieve the National Drug Abuse Treatment Clinical Trials Network (CTN) goal of improving outcomes of community-based drug treatment. These partnerships blend clinical perspectives of practitioners and methodological expertise of researchers working together to address clinically meaningful issues through randomized clinical trials conducted in community treatment settings. Though bidirectionality is a guiding principle of the CTN, its operationalization at the practical level in protocol development and implementation has not been articulated. This article describes the development of one protocol as an example and model of this bidirectional, collaborative, iterative partnership between researchers and practitioners (protocol CTN-0039). The STAGE-12 protocol, a behavioral intervention to facilitate 12-step mutual support group involvement, was successfully developed through a series of decisions taking into account both design factors and clinical practice needs and realities, thus maintaining a balance between methodological rigor and generalizability.

Conclusion: This review demonstrates the process by which research and practice have been blended in protocol development, exemplifying the underlying principle of bidirectionality, a key element in the success of the NIDA CTN. Bidirectional partnerships as derived in the CTN, employing a hybrid model of efficacy-effectiveness research, are capable of designing and implementing protocols that are both methodologically rigorous and clinically meaningful, thus increasing likelihood of adoption and eventual improvement in public health.

Related protocols: CTN-0031