A scoping review of implementation strategies to reduce stigma toward people who use substances in healthcare settings.

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Background: Stigma toward people with substance use disorders (SUD) remains a major barrier to care. There have been multiple calls to action to address SUD stigma in healthcare settings and other reviews have clarified the need for more rigorous effectiveness research. In addition to attention to effectiveness research, there is a need to attend to the implementation strategies used to deliver SUD stigma reduction interventions. Delineating discrete implementation strategies that have been used to address stigma will support future research efforts to arrive at the most optimal interventions to address SUD stigma.

Methods: We searched three databases and extracted data to identify interventions tested to reduce SUD stigma. We used the adapted Expert Recommendations for Implementing Change (ERIC) taxonomy to characterize the discrete implementation strategies used to support the adoption, implementation, sustainment, and scale-up (or spread) of each intervention.

Results: This scoping review synthesized 108 peer-reviewed studies reporting on interventions which to address SUD stigma among healthcare professionals. Most interventions were implemented in training environments, including higher education and continuing education settings, and focused on providing basic education on SUD broadly or opioid use disorder. Within interventions, educational and training implementation strategies were most prominent with 74% of studies using educational meetings and 39% distributing training materials. Far fewer studies used implementation strategies that used experiential approaches such interactive assistance, simulation, case-based learning, or contact with people with lived experience. Most studies (73%) reported reductions in stigmatizing attitudes, most often immediately post-intervention, though the need for higher study quality was notable.

Conclusions: Existing stigma-reduction interventions are overwhelmingly education-focused and primarily implemented in academic settings, with limited use of strategies that promote reflective learning, contact-based engagement, or organizational change. Future work should employ more rigorous designs that systematically test implementation strategies to create packaged SUD stigma reduction interventions optimized for effectiveness and implementation.

Categories: CTN Translation & Implementation SIG, Implementation, Stigma
Tags: Article (Peer-Reviewed)
Authors : Cioffi, Camille; Baloh, Jure; Brunner, Meg; Cheng, Hannah; DiFiore, Emma; Davis, April D.; Fenstemaker, Cheyenne; Fisher, Sycarah; Finlayson, Reid; Franz, Berkeley; Franz, Daschel; Hosseini, Mohammad Ali; Rains, Alex N.; Schmidt, Alex; Smith, Crystal; Vest, Noel; Hartzler, Bryan; CTN Implementation Strategies Workgroup
PMID : 42069061
Source : Journal of Substance Use and Addiction Treatment 2026 (in press). [doi: 10.1016/j.josat.2026.210005]