Cocaine Use Reduction with Buprenorphine (CURB: CTN-0048): Protocol overview.

This protocol-specific training webinar, hosted by the NIDA Clinical Coordinating Center, provides an overview of the National Drug Abuse Treatment Clinical Trials Network (CTN) study, protocol CTN-0048 (Cocaine Use Reduction with Buprenorphine (CURB)). This study is a randomized, double-blind, placebo-controlled trial designed to examine the safety and effectiveness of buprenorphine in the presence of naltrexone for individuals with cocaine dependence and past-year opioid dependence, past-year opioid abuse, or past-year opioid use with a history of opioid dependence during the participant’s lifetime. The chemical mechanisms of both cocaine and opioids are discussed, along with the effects of withdrawal from both substances. Also included are study participant inclusion/exclusion criteria, a list of the screening assessments that will be used, and information about both buprenorphine and naloxone and the dosing specifics that will be used in the trial itself.

Related protocols: CTN-0048