The primary objective of this study is to replicate the finding that performance on the Stroop color-word interference task is predictive of treatment completion in participants with cocaine use disorders and to extend this finding to participants with METH use disorders. Secondary objectives include evaluating whether: 1.) performance on various neurocognitive tests, including the Stroop, Rey Auditory-Verbal Learning Test (RAVLT), Iowa Gambling Task (GT), Wisconsin Card Sorting Task (WCST), and the Barratt Impulsiveness Scale version -11 (BIS-11) is predictive of treatment attrition and stimulant use outcomes in METH/cocaine abusers; 2.) neurocognitive test performance is associated with oxidative damage, a severe consequence of oxidative stress, in METH/cocaine abusers; 3.) oxidative damage, as assessed by two plasma measures, is predictive of treatment attrition and substance use outcomes in METH/cocaine abusers, and 4.) oxidative damage in METH/cocaine abusers is significantly greater than that of a normal comparison group.
Methamphetamine-dependent and cocaine-dependent patients may have different impulsivity profiles but the BIS-11 may be useful in identifying both methamphetamine-dependent and cocaine-dependent patients who are at risk for treatment non-completion.
Results Article: Winhusen et al. Impulsivity is Associated with Treatment Non-Completion in Cocaine- and Methamphetamine-Dependent Patients but Differs in Nature as a Function of Stimulant-Dependence Diagnosis. Journal of Substance Abuse Treatment 2013;44(5):541-547. [get article]
- CTN-0031: Stimulant Abusers Group to Engage in 12-Step (STAGE-12)
- CTN-0031-A-2: The Role of Alcohol Consumption in Classifications of Alcohol Use Disorders: A Clinical Study
- CTN-0031-A-3: Organizational and Practitioner Influences on Implementation of STAGE-12
- CTN-0031-A-1 Study Protocol
- Publications in the Library about CTN-0031-A-1
- Study data from NIDA Data Share
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