CTN-0044-A-1: Site Influences on Treatment Effects – Web-Delivery of Evidence-Based, Psychosocial Treatment for Substance Use Disorders

November 29, 2021 /

Dennis McCarty, PhD
Lead Investigator
Oregon Health & Science University

Site variations in study outcomes are apparent in clinical trials conducted within the National Drug Abuse Treatment Clinical Trials Network (CTN).  Systematic and standardized collection of organizational and workforce variables may help elucidate site variations and increase the CTN’s understanding of patient outcomes in protocols.  The Web-Delivery of Evidence-Based, Psychosocial Treatment for Substance Use Disorders study (CTN-0044) will be used to assess the influence of organizational and workforce characteristics on trial operations (e.g., rates of participant recruitment and follow-up) and patient outcomes (e.g., reductions in drug use).  This study will build on the analysis of organizational and workforce data in the Baseline Protocol (CTN-0008) and the collection of pre-implementation site data for STAGE-12 (CTN-0031-A-3).  The study’s specific aim is the assessment of associations between site organizational and practitioner variables and site differences in clinical trial outcomes.

Primary Findings

Analysis of the intention to adopt a web-delivered intervention assessed the influence of attitudes and perceived social norms. Perceived social norms were a significant contributor to clinician intention to adopt web-based interventions, while attitude was not. To promote successful implementation, it may be helpful to create social norms supportive of computer-assisted therapies.

Results Article: Buti AL, Eakins D, Fussell HE, et al. Clinician Attitudes, Social Norms and Intentions to Use a Computer-Assisted Intervention. Journal of Substance Abuse Treatment 2013;44:433–437. [get article]

    Node Involvement

    Lead Node(s):

  • Western States Node

    • All Participating Nodes:

  • Western States Node