CTN-0082: Implementation Survey of PrEP and Opioid Use Related Services In STI Clinics and Community Based Organizations (CBOs)

Susan Tross, PhD
Co-Lead Investigator
Columbia University

Mary Hatch, PhD
Co-Lead Investigator

University of Washington

PrEP is an effective means of prevention of HIV infection but not used by high risk individuals, especially those who use substances, in all regions. Similarly, effective approaches to opioid use, especially Medication Assisted Treatment, medication to reverse overdose, and counseling, are not used universally by those in need.

This study will obtain data essential for implementation of PrEP services and Opioid Use services to higher risk people who use drugs (PWUD), especially (1) men who have sex with men (MSM) who use stimulants and club drugs and (2) PWUD who use opioids, in STI clinics and community-based organizations (CBOs), in eight Southern cities with highest HIV incidence. This study will be a single-assessment, multi-level [agency director (N=16), provider (N=≤320), (stimulant/club drug-using MSM and opiate-using) consumer (N=480)] implementation survey study.

Primary and secondary outcome data will describe extent of and nature of knowledge of, interest in, perceived barriers and facilitators to, and suggested strategies for implementing PrEP-related and opioid use-related services in these three major types of stakeholders. Opioid use-related services will include a) medication assisted treatment (MAT) for opioid use disorder (OUD); b) psychosocial counseling; c) opioid overdose prevention services; and d) syringe services. Exploratory analyses will use the iPARIHS (Integrated Promoting Action on Research Implementation In Health Services) framework to examine predictors for knowledge, experience and willingness, to use or link to pre-exposure prophylaxis (PrEP) and opioid use-related services. Structural-, provider- and consumer-level predictors will be analyzed to inform readiness for PrEP and opioid-use services.

Primary Findings

PWUO in this study were amenable to PrEP, particularly in light of education and condomless vaginal sex. Careful consideration for matching PrEP messaging to the PWUO audience is needed. PrEP promotion should expand beyond men who have sex with men to include groups such as these predominantly heterosexual, polysubstance-using PWUO with HIV risk who were open to both formulations of PrEP.

Primary Outcomes Article: Hatch MA, et al. PrEP for People Who Use Opioids: A NIDA Clinical Trials Network Survey Study in Southern U.S. Cities Where HIV Incidence is High. Drug and Alcohol Dependence 2024;257:111133. [get article]

    Node Involvement

    Lead Node(s):

  • New York Node
  • Pacific Northwest Node

  • All Participating Nodes:

  • Florida Node Alliance
  • New York Node
  • Pacific Northwest Node