CTN-0098: Exemplar Hospital Initiation Trial to Enhance Treatment Engagement (EXHIT ENTRE)

Gavin Bart, MD, PhD, FACP, FASAM
Co-Lead Investigator

Minneapolis Medical Research Foundation
Hennepin County Medical Center

Richard Saitz, MD, MPH, FACP, DFASAM
Co-Lead Investigator

Boston University School of Public Health

Hospital inpatient stays due to opioid-related health problems are a reachable moment for increasing access to treatment with medications for opioid use disorder (MOUD). Hospitalized patients with opioid use disorder (OUD) are at particularly high risk for morbidity, mortality, and high medical costs in the U.S.

This study will substantially inform the care management of OUD in hospitalized patients. The project includes a comparative effectiveness research trial, and an implementation-research trial, which will lead to models of broad dissemination for treatment approaches to this largely unaddressed population.

They will examine whether: 1) in hospitals with addiction medicine consultation services, hospital-initiated extended release buprenorphine (XR-BUP), compared to other OUD medications, results in increased engagement in treatment with MOUD following hospital discharge; and 2) training hospitals without such consultation services on best practices for initiating MOUD using consultation service hubs improves medication uptake in hospitals and increased MOUD treatment engagement following discharge.

Funded by the NIH HEAL InitiativeSM.

    Node Involvement

    Lead Node(s):

  • Northstar Node
  • Western States Node

  • All Participating Nodes:

  • Northstar Node
  • Western States Node