CTN-0152: Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder: A Pragmatic, Multi-Site, Double-Blind, Randomized, Placebo-Controlled Trial (TAB)
T. John Winhusen, PhD
Lead Investigator
University of Cincinnati
winhust@ucmail.uc.edu
Buprenorphine is an evidence-based treatment for opioid use disorder. However, buprenorphine, as a stand-alone pharmacotherapy, has limitations including challenges with treatment retention and patient experiences of craving for, and/or use of, illicit opioids and other substances. Research suggests that glucagon-like peptide-1 (GLP-1) agonists may ameliorate substance craving and use. The TAB trial will test tirzepatide, which is a GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) agonist, as an adjunct to buprenorphine for the treatment of opioid use disorder.
Funded by the NIH HEAL Initiative℠.
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