CTN-0028: Osmotic-Release Methylphenidate for ADHD in Adolescents with Substance Use Disorders

Paula Riggs, MD
Co-Lead Investigator
University of Colorado at Denver
Health Sciences Center

T. John Winhusen, PhD
Co-Lead Investigator
University of Cincinnati
Addiction Sciences Division

The primary objectives of this study were to evaluate the efficacy of OROS-MPH (Concerta), relative to placebo, in treating ADHD and decreasing substance use in adolescents with ADHD and a substance use disorder.  The study involved 303 participants, recruited from 11 community treatment sites.

Primary Findings

OROS-MPH did not show greater efficacy than placebo for ADHD or on reduction in substance use in adolescents concurrently receiving individual CBT for co-occurring SUD. However, OROS-MPH was relatively well tolerated and was associated with modestly greater clinical improvement on some secondary ADHD and substance outcome measures.

Primary Outcomes Article: Riggs PD, et al. Randomized Controlled Trial of Osmotic-Release Methylphenidate with CBT in Adolescents with ADHD and Substance Use Disorders. Journal of the American Academy of Child and Adolescent Psychiatry 2011 (in press). [get article]

    Node Involvement

    Lead Node(s):

  • Ohio Valley Node
  • New England Consortium

  • All Participating Nodes:

  • Appalachian Tri-State Node
  • Delaware Valley Node
  • Florida Node Alliance
  • Mid-Atlantic Node
  • New England Consortium
  • New York Node
  • Ohio Valley Node
  • Southern Consortium Node
  • Texas Node