What’s New in the CTN?
Updates from the NIDA National Drug Abuse Treatment Clinical Trials Network. Want to share some news about your protocol, node, publications or presentations, or other CTN-related work here and/or in the CTN Bulletin? Email us at ctnlib@uw.edu!
Primary Care SIG Meeting: March 24, 2025 (9-10am PT/12-1pm ET)
The Primary Care SIG aims to engage primary care in research, develop substance use treatment interventions relevant to community-based practice, and promote the transfer of evidence-based results from substance use research into community-based practices. Primary Care SIG Key Objectives Primary Care SIG Webinars and presentations The Primary Care SIG is led by Joe LeMaster, MD, MPH and Sebastian Tong, MD, MPH, and meets every other month on the 4th Monday of the month from 9-10am PT/12-1pm ET. To join the Primary Care SIG webinar series listserv, please provide your contact…
Northeast Node Science Series Webinar: Cannabis: Therapeutic Use and Consequences (April 10, 2025,12-1pm ET)
The landscape of cannabis research has sharpened in recent years, with new understandings of what is therapeutically beneficial and what is not. There is a great diversity in cannabis products and nearly as many ways to consume it, with more US states seeking legalization of both medicinal and recreational use. In this presentation, Dr. Alan Budney will review the state of the science related to the clinical efficacy of cannabis use and discuss alternative ways to consider and act on what is known. He will also review the potential consequences…
News from the Pacific Northwest Node
The Pacific Northwest Node will be presenting four CTN-related posters at this year’s College on Problems of Drug Dependence (CPDD) conference in New Orleans (June 14-18, 2025): Authors from the node also have a new paper out, related to CTN-0082: Attitudes Toward and Experience with Naloxone Among People Who Use Drugs in the Southeastern United States. Le MH, et al. International Journal of Drug Policy 2025; 139: 10479. Find it in the CTN Dissemination Library. Posted on March 12, 2025
Virtual CTN Steering Committee Meeting: March 11, 1-5pm ET
The National Institute on Drug Abuse (NIDA) Center for the Clinical Trials Network (CCTN) is hosting a virtual Quarterly Steering Committee Meeting on Tuesday, March 11, 2025 from 1:00 – 5:00 p.m. Eastern. View agenda | Register for the meeting Once registered you will receive the Zoom information, including an option to download a calendar invitation. If you have any questions about the meeting logistics, please contact CTNSupport@sdsolutionsllc.com. Individuals with disabilities who need sign language interpreting and/or other reasonable accommodations to participate in this event should contact Sean Randol at (202) 258-3638…
CTN T&I SIG Session: A Pragmatic Measure of Context at the Organizational Level: The IFASIS (March 18, 9am PT)
Title: A Pragmatic Measure of Context at the Organizational Level: The Inventory of Factors Affecting Successful Implementation and Sustainment (IFASIS)Date/time: March 18, 2025, 9-10am PTSpeaker: Helene Chokron Garneau, PhD, MPH (Senior Research Scientist at Stanford University School of Medicine and co-Director of the Center for Dissemination and Implementation At Stanford (C-DIAS). Download/share the flyer (image file). Successful implementation and sustainment of interventions is heavily influence by context. Yet the complexity and dynamic nature of context make it challenging to connect and translate findings across implementation efforts, limiting potential replicability and…
Update from the CTN CCC and DSC
The CCC and DSC are pleased to announce a new resource on the CTN TPR Website: The CTN Sample Document Repository, a reference library of over 100 sample study documents developed by a working group of Node Coordinators and Project Directors from recent CTN studies. Sample study documents consist of training materials, recruitment and retention documents, as well as sample documents required for Protocol Review Board submission, among others. The CTN Sample Document Repository is a collaborative effort between the CTN Nodes, CCC, and DSC. Sample documents were developed and submitted by…
News from the Health System Node: Spotlight on Gwen Lapham, PhD, MPH, MSW
Spotlight on Health System Node Investigator – Gwen Lapham, PhD, MPH, MSW CTN studies often have many important secondary findings and Dr. Lapham, a CTN investigator in the Health Systems Node, has been making sure these get published rapidly. In 2024, Dr. Lapham led a paper on Year 3 outcomes of the PROUD Trial (CTN-0074) in JAMA Network Open, showing that the benefit of the PROUD nurse care manager intervention more than doubled during year 3 (compared to years 1-2 in the main results paper) with significant benefit in 4 of…
News from the Appalachian Node
The Appalachian Node has received a notice of award for funding for the next seven years (FY25 – FY32). We are excited to welcome to our newest partners, University of Maryland Baltimore and the PATH Network.
New in the Library (January-February 2025)
Here are the latest items added to the CTN Dissemination Library for January – February 2025 (this post will be updated as new items come in): Predictors of Participation in Prenatal Substance Use Assessment, Counseling, and Treatment Among Pregnant Individuals in Prenatal Settings Who Use Cannabis. Lapham GT, et al. Journal of Addiction Medicine 2024 (in press). (CTN-0140) Optimizing Retention Strategies for Opioid Use Disorder Pharmacotherapy: The Retention Phase of the CTN-0100 Trial (RDD). Shulman M, et al. Contemporary Clinical Trials 2025;107816 (in press). (CTN-0100) Age, Period, and Cohort Effects…
CTN-0096 (Tribal MOUD): Notice of Data Lock Completion
Culturally Centering Medications for Opioid Use Disorder with American Indian and Alaska Native Communities (CTN-0096, Tribal MOUD) – Notice of Data Lock Completion Incorporating American Indian and Alaska Native (AI/AN) traditional practices and knowledge into healthcare can support AI/AN health. Despite higher rates of abstinence, AI/AN experience the highest rates of overdose mortality due to the ongoing impact of colonization, historical trauma, discriminatory policies, and under-resourced healthcare. Medications for opioid use disorder (MOUD; e.g., buprenorphine, methadone, naltrexone) are the most effective treatment for reducing opioid-related mortality. CTN-0096 (Tribal MOUD) was…
News from the Pacific Northwest Node
The Pacific Northwest Node of the NIDA Clinical Trials Network, located at the UW Addictions, Drug & Alcohol Institute and directed by Mary Hatch, PhD, and John Roll, PhD, had a very productive 2024, with 4 published papers and 4 more in the works! New Publications First, they recently participated in the publication of four papers from CTN-0082, Implementation Survey of PrEP and Opioid Use Related Services in STI Clinics and Community Based Organizations (CBOs), including two outcomes papers (first two listed here): The two outcome papers found that people…
News from the Northeast Node: ED Treatment of OUD webinar (Feb 6, 9am PT)
Join the Northeast Node on February 6 (9am-10am PT) for the next installment in their Science Series: Emergency Department Treatment of Opioid Use Disorder: Innovation & Discovery. Opioid use disorder (OUD) took the lives of an estimated 107,543 people in the United States in 2023, yet medications to treat OUD are effective and widely available. Emergency departments are a 24/7/365 option for combating this crisis and saving lives. In this presentation, Dr. Gail D’Onofrio will discuss the evidence regarding initiation of buprenorphine in the ED, describe innovations in dosing and…
Injectable Buprenorphine: New Factsheets from CTN PNW Node
Buprenorphine is one of three medications (methadone and naltrexone being the other two) approved for use to treat opioid use disorder. It is available as a film or tablet, and more recently as two long-acting extended-release injectables. Sublocade™ was first to be approved by the FDA in November 2017. More recently, in May 2023, Brixadi™ received approval. In January 2024 it was added to the WA state Medicaid formulary. Fewer clinicians have experience using Brixadi™ than Sublocade™. The CTN Pacific Northwest Node recently developed a set of videos intended to aid prescribers in their…
New in the Library (December 2024 – January 2025)
Here are the latest items added to the CTN Dissemination Library for December 2024 -January 2024 (this post will be updated as new items come in): Willingness to Use Oral and Long-Acting Injectable PrEP in Substance-Using Men Who Have Sex with Men (SU-MSM) in High HIV Incidence Southern U.S. Cities: A NIDA Clinical Trials Network Study. Tross S, et al. AIDS and Behavior 2024 (in press). (CTN-0082 outcomes) HIV Prevention in Syringe Service Programs Since the Start of COVID-19: Where Do We Go From Here? Hatch MA, et al. Current…
NIDA Drug Repurposing and Repositioning Insights for Treating Substance Use Disorders Challenge
The NIDA “Drug Repurposing and Repositioning Insights for Treating Substance Use Disorders (SUDs)” Challenge aims to inspire and gather groundbreaking ideas for repurposing or repositioning existing drugs to effectively treat substance use disorders. By focusing on existing drugs, new therapeutic approaches can rapidly be translated into clinical practice, bringing new hope to individuals struggling with SUD. The Challenge will offer up to ten awards of up to $10,000 each. The Challenge total cash prize purse is up to $100,000. Challenge participants and winners may also have the opportunity to collaborate…
New in the Library (November-December 2024)
Here are the latest items added to the CTN Dissemination Library for November-December 2024 (this post will be updated as new items come in): Factors Associated with PrEP Awareness and Use Among Men Who Have Sex with Men Who Use Drugs in the Southern United States. Paschen-Wolff M, et al. AIDS Care 2024 (in press). (CTN-0082) Efficient and Flexible Mediation Analysis with Time-Varying Mediator, Treatments, and Confounders. Díaz I, Journal of Causal Inference 2023;11(1):20220077. (CTN-0051) Pharmacy-Based Preventive Services for Opioid Use Disorder: A Survey of U.S. Pharmacists. Wu L, et al….
Western States Node/ATTC Webinar: Cannabis Use During Pregnancy: Research from Policy to Practice (Feb 12, 11am PT)
In this webinar sponsored by the Western States Node and the Northwest and Pacific Southwest ATTCs, Kelly Young-Wolff, PhD, MPH (a licensed clinical psychologist and research scientist at the Kaiser Permanente Northern CA Division of Research) will describe what is known about prenatal cannabis use trends and health consequences using data from Kaiser Permanente Northern California’s large integrated healthcare delivery system. She will discuss why pregnant individuals use cannabis, describe disparities in prenatal cannabis use and related outcomes, and end with a discussion about the potential harms of punitive policies…
Youth SIG Webinar: Age, Period, and Cohort Effects in Alcohol and Other Substance Use (Jan 17, 11am ET)
Join the CTN Youth SIG for their next webinar, “Age, Period, and Cohort Effects in Alcohol and Other Substance Use: Implications for Health and Prevention,” presented by Katherine M. Keyes, PhD (Columbia University), on Friday, January 17, 2025, 11am-12pm ET. Incidence, prevalence, and persistence of substance use differ by generation and by substance. Understanding how each generation uses alcohol and other drugs, why, and how health is implicated is critical for public health. The presentation will overview what we know about current trends in substance use, how rates are organized…
CTN Primary Care SIG Webinar: Engaging Rural Communities and Practices in Substance Use Research (Jan. 27, 12pm ET)
The NIH recently launched a $30 million Communities Advancing Research Equity (CARE) for Health Initiative, which funds primary care research network hubs to engage rural communities and practices in research. As part of the pilot, CTN-0139 (Co-Care) is engaging with two newly funded rural hubs to expand engagement and recruitment in small rural practices. The January 27, 2025 Primary Care SIG meeting (12pm ET, 9am PT) will feature a panel to discuss how CARE for Health synergistically can enhance and contribute to CTN trials. The panel will include: Connect to the Zoom meeting.ID:…