• Injectable Bupe in practice
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    Injectable Buprenorphine: New Factsheets from CTN PNW Node

    Buprenorphine is one of three medications (methadone and naltrexone being the other two) approved for use to treat opioid use disorder. It is available as a film or tablet, and more recently as two long-acting extended-release injectables. Sublocade™ was first to be approved by the FDA in November 2017. More recently, in May 2023, Brixadi™ received approval. In January 2024 it was added to the WA state Medicaid formulary. Fewer clinicians have experience using Brixadi™ than Sublocade™. The CTN Pacific Northwest Node recently developed a set of videos intended to aid prescribers in their conversations with patients interested in these buprenorphine options, and have now added two new factsheets too: Injectable Buprenorphine: Getting Started Injectable Buprenorphine: Logistical Info for Clinics Find the complete set of resources here!

  • New in the Library
    New in the Library

    New in the Library (December 2024 – January 2025)

    Here are the latest items added to the CTN Dissemination Library for December 2024 -January 2024 (this post will be updated as new items come in): Willingness to Use Oral and Long-Acting Injectable PrEP in Substance-Using Men Who Have Sex with Men (SU-MSM) in High HIV Incidence Southern U.S. Cities: A NIDA Clinical Trials Network Study. Tross S, et al. AIDS and Behavior 2024 (in press). (CTN-0082 outcomes) HIV Prevention in Syringe Service Programs Since the Start of COVID-19: Where Do We Go From Here? Hatch MA, et al. Current HIV/AIDS Reports 2025;22:13. Cost-Effectiveness of Implementation Facilitation to Promote Emergency Department-Initiated Buprenorphine for Opioid Use Disorder. Lu T, et al. Annals of Emergency Medicine 2024 (in press). (CTN-0069) Racial and Ethnic Differences in Long-Term Outcomes Among Individuals with Opioid Use Disorder at Opioid Treatment Programs. Zhu Y, et al. Journal of Racial and Ethnic Health Disparities 2024 (in press). (CTN-0050) Data Cleaning and Harmonization of Clinical Trial Data: Medication-Assisted Treatment for Opioid Use Disorder. Balise RR, et al. PLoS ONE 2024;19(11):e0312695. (CTN-0027, CTN-0030, CTN-0051) Nurse Care Management of Opioid Use Disorder Treatment After 3 Years: A Secondary Analysis of the PROUD Cluster Randomized Clinical Trial. Lapham GT, et al. JAMA Network Open 2024;7(11):e2447447. (CTN-0074) Posted on January 7, 2025.

  • White paper airplanes with a red one flying off ahead
    Other

    NIDA Drug Repurposing and Repositioning Insights for Treating Substance Use Disorders Challenge

    The NIDA “Drug Repurposing and Repositioning Insights for Treating Substance Use Disorders (SUDs)” Challenge aims to inspire and gather groundbreaking ideas for repurposing or repositioning existing drugs to effectively treat substance use disorders. By focusing on existing drugs, new therapeutic approaches can rapidly be translated into clinical practice, bringing new hope to individuals struggling with SUD. The Challenge will offer up to ten awards of up to $10,000 each. The Challenge total cash prize purse is up to $100,000. Challenge participants and winners may also have the opportunity to collaborate with the center focused on drug repurposing that NIDA anticipates funding in the future. The submission deadline for this Challenge competition is January 8, 2025, so learn more and submit your solution today! Learn more and apply here!

  • New in the Library
    New in the Library

    New in the Library (November-December 2024)

    Here are the latest items added to the CTN Dissemination Library for November-December 2024 (this post will be updated as new items come in): Factors Associated with PrEP Awareness and Use Among Men Who Have Sex with Men Who Use Drugs in the Southern United States. Paschen-Wolff M, et al. AIDS Care 2024 (in press). (CTN-0082) Efficient and Flexible Mediation Analysis with Time-Varying Mediator, Treatments, and Confounders. Díaz I, Journal of Causal Inference 2023;11(1):20220077. (CTN-0051) Pharmacy-Based Preventive Services for Opioid Use Disorder: A Survey of U.S. Pharmacists. Wu L, et al. Addiction Science & Clinical Practice 2024;19:88. (primary outcomes for CTN-0105) CTN-0138: Adaptation, Implementation, and Cluster Randomized Trial of a Community Pharmacy-Based Prescription Drug Monitoring Program Opioid Risk Assessment Tool — A Protocol Paper. Cochran GT, et al. Addiction Science & Clinical Practice 2024;19:82. (CTN-0138) Artificial Intelligence-Based Drug Repurposing with Electronic Health Record Clinical Corroboration: A Case for Ketamine as a Potential Treatment for Amphetamine-Type Stimulant Use Disorder. Gao Z, et al. Addiction 2024 (in press). (CTN-0114) Posted November 18, 2024, updated December 18, 2024

  • Cannabis Use During Pregnancy, Feb 12, 11am PT
    Events,  Node News

    Western States Node/ATTC Webinar: Cannabis Use During Pregnancy: Research from Policy to Practice (Feb 12, 11am PT)

    In this webinar sponsored by the Western States Node and the Northwest and Pacific Southwest ATTCs, Kelly Young-Wolff, PhD, MPH (a licensed clinical psychologist and research scientist at the Kaiser Permanente Northern CA Division of Research) will describe what is known about prenatal cannabis use trends and health consequences using data from Kaiser Permanente Northern California’s large integrated healthcare delivery system. She will discuss why pregnant individuals use cannabis, describe disparities in prenatal cannabis use and related outcomes, and end with a discussion about the potential harms of punitive policies that penalize or criminalize prenatal substance use. At the conclusion of the webinar, participants will be able to: 1.5 CME or CE credits available! (Select credit type when you register; learn more about available credit types here) Sponsored by the Northwest and Pacific Southwest Addiction Technology Transfer Centers (ATTCs) and the Western States Node of the NIDA Clinical Trials Network. Learn more and register here!

  • CTN Youth SIG: Upcoming Webinar
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    Youth SIG Webinar: Age, Period, and Cohort Effects in Alcohol and Other Substance Use (Jan 17, 11am ET)

    Join the CTN Youth SIG for their next webinar, “Age, Period, and Cohort Effects in Alcohol and Other Substance Use: Implications for Health and Prevention,” presented by Katherine M. Keyes, PhD (Columbia University), on Friday, January 17, 2025, 11am-12pm ET. Incidence, prevalence, and persistence of substance use differ by generation and by substance. Understanding how each generation uses alcohol and other drugs, why, and how health is implicated is critical for public health. The presentation will overview what we know about current trends in substance use, how rates are organized by age, period, and cohort, and how these trends are shaping public health overall. About the presenter Katherine M. Keyes, PhD, is Professor of Epidemiology at the Columbia University Mailman School of Public Health. Dr. Keyes’ research focuses on psychiatric and substance use epidemiologyacross the life course, including early and cross-generational origins of child and adult health and cohort effects on substance use, mental health, and injury outcomes including suicide and overdose. She is the author of more than 450 peer-reviewed publications, and two textbooks. Register here!

  • CTN Primary Care SIG
    Events,  SIG Updates

    CTN Primary Care SIG Webinar: Engaging Rural Communities and Practices in Substance Use Research (Jan. 27, 12pm ET)

    The NIH recently launched a $30 million Communities Advancing Research Equity (CARE) for Health Initiative, which funds primary care research network hubs to engage rural communities and practices in research. As part of the pilot, CTN-0139 (Co-Care) is engaging with two newly funded rural hubs to expand engagement and recruitment in small rural practices.  The January 27, 2025 Primary Care SIG meeting (12pm ET, 9am PT) will feature a panel to discuss how CARE for Health synergistically can enhance and contribute to CTN trials. The panel will include: Connect to the Zoom meeting.ID: 996 0835 1363Passcode: 291918 Questions? Contact Maria Prado at pradom@uw.edu.

  • Young woman looking at laptop and smiling
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    Recording available: NIDA CTN: Future of AI in Medicine: Medical Imaging as an Example

    A recording of this webinar, held on November 20, 2024, is now available! (passcode: N7A3h^SX) Presenter:Dr. Curt LanglotzProfessor of Radiology, Medicine, and Biomedical Data ScienceSenior Associate Vice Provost for ResearchDirector, Center for Artificial Intelligence in Medicine & ImagingSenior Fellow, Institute for Human-Centered Artificial Intelligence Artificial intelligence (AI) is an incredibly powerful tool for building systems that support the work of clinicians and researchers. Over the last decade, machine learning methods have revolutionized the analysis of medical data, leading to high interest and explosive growth in the use of AI and machine learning methods. These promising techniques create systems that perform some clinical tasks at the level of expert physicians. Deep learning methods in imaging are now being developed for image reconstruction, imaging quality assurance, imaging triage, computer-aided detection, computer-aided classification, and radiology report drafting.  The systems have the potential to provide real-time assistance to radiologists and other imaging professionals, thereby reducing diagnostic errors, improving patient outcomes, and reducing costs.  We will review the origins of AI and its applications to medicine, and medical imaging, define key terms, and show examples of real-world applications that suggest how AI may change the practice of medicine.  We will also review key shortcomings and challenges that may limit the application of these new methods. About the presenter Curtis P. Langlotz, MD, PhD : Dr. Langlotz is Professor of Radiology, Medicine, and Biomedical Data Science, and Senior Associate Vice Provost for Research at Stanford University. His NIH-funded laboratory develops machine learning methods to improve the accuracy and…

  • Hands on a keyboard with text overlayed that reads APPLY NOW
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    NIDA Diversity Scholars Network Program Now Accepting Applications!

    The NIDA Office of Research Training, Diversity, and Disparities (ORTDD) is excited to share that the 2025 NIDA Diversity Scholars Network (NDSN) program is now accepting applications!  The deadline to apply is January 31, 2025! NIDA is seeking applications from individuals from diverse backgrounds, including those from underrepresented groups, who are interested in conducting substance use and addiction research. The NDSN is a grant-writing program aimed at enhancing the funding success of early-stage investigators. The program consists of three workshops and culminates in a mock review meeting experience. Questions? Contact Isabela Ellenwood (NDSN@nih.gov). Learn more and apply here!

  • CTN Youth SIG: Upcoming webinar
    Events,  SIG Updates

    Youth SIG Webinar Recording Available: Scaling Out Evidence-Based Interventions Through Primary Care Settings: A Case Study of the PAAS Program

    The CTN Youth SIG hosted the following webinar in November 2024. The recording is now available! Title: Scaling Out Evidence-Based Interventions Through Primary Care Settings: A Case Study of the Pathways for African Americans (PAAS) Program Presenter:Velma McBride Murry, PhDLois Autrey Betts Endowed ChairCo-Director, Vanderbilt University Medical Center Program for Health Equity ResearchDistinguished University Professor, Departments of Health Policy & Human and Organizational Development, Vanderbilt University This presentation highlighted the role of primary care setting as a conduit for evidence-based intervention access for families. In addition, attention was given the need to focus on system level interventions to reduce the need for families and youth to be “resilient.” Dr. Velma McBride Murry holds the Lois Autrey Betts Endowed Chair, previously held an appointed position of Associate Provost, Research and Innovation, currently serves as Co-Director of the Vanderbilt University Medical Center Program for Health Equity Research (PHER), and is a University Distinguished Professor in Departments of Health Policy [Vanderbilt School of Medicine] and Human and Organizational Development [Peabody College]. She is Past President of the Society for Research on Adolescence and current President of The International Consortium of Developmental Science Societies. McBride Murry is one of the 100 elected members to the 2020 Class of the National Academic of Medicine.  She is an appointed standing member of National Institutes of Health National Advisory Mental Health Research Council. Her research examines the significance of context to everyday life experiences of African American families and youth, focusing on processes through which racism, and other social structural stressors, cascade through families to…