Here are the latest items added to the CTN Dissemination Library for July – August 2024 (this post will be updated as new items come in): Performance of the Tobacco, Alcohol, Prescription Medication, and Other Substance Use (TAPS) Tool in Screening Older Adults for Unhealthy Substance Use. Han BH, et al. Journal of Addiction Medicine 2024 (in press). (CTN-0059) Analyzing Quality of Life Among People with Opioid Use Disorder from the National Institute on Drug Abuse Data Share Initiative: Implications for Decision Making. Patton T, et al. Quality of Life Research 2024 (in press). (multiple protocols) Delivering MOUD to the Underserved: How Can Pharmacies Really Help? Gustafson DH, et al. Journal of Studies on Alcohol and Drugs 2024 (in press). (CTN-0124 Primary Outcomes) High Suicidality Predicts Overdose Events Among People with Substance Use Disorder: A Latent Class Analysis. Schmidt RD, et al. Frontiers in Public Health 2023;11:1150062. (multiple protocols) Association of Psychiatric and Substance Use Disorders with Cannabis Use and Cannabis Use Disorder During Early Pregnancy in Northern California. Young-Wolff KC, et al. Addiction 2024 (in press). (CTN-0140) Psychosocial Factors Linked to Uncontrolled Infection and Mortality Among People Living with HIV Who Use Substances: A Latent Class Analysis. Schmidt RD, et al. AIDS and Behavior 2024 (in press). (CTN-0049, CTN-0064) Suicide and Cannabis Use Among Youth & Young Adults. Hammond CJ & Hinckley JD. CTN Youth Special Interest Group (SIG) webinar, July 2024 Discriminative Validity of a Substance Use Symptom Checklist for Moderate-Severe DSM-5 Cannabis Use Disorder (CUD) in…

The primary outcomes paper for CTN-0124, Assessment and Design of a Cost-Effective Collaborative MOUD Delivery System, is now available! Citation: Gustafson DH, Molfenter T, Kunes T, Langdon L, Koplin M, Parker F, Branny K, Ghitza U, Bart G. Delivering MOUD to the Underserved: How Can Pharmacies Really Help? Journal of Studies on Alcohol and Drugs 2024 (in press). What’s the question? Access to treatment for opioid use disorder (OUD) is a challenge in rural settings and for communities of color, partly because of the limited availability of healthcare providers equipped and willing to provide medications for OUD (MOUD). Pharmacies have been increasingly proposed as one way to enhance access to MOUD, as they are often more available in rural and other underserved communities than primary care physicians or other prescribers. A key question, however, is whether or not pharmacies are adequately prepared to distribute medications and other resources to people with OUD. This study aimed to answer that question by examining the potential role of pharmacies in MOUD delivery, looking at what barriers exist, and proposing actionable strategies for improvement. How was this study conducted? To address this issue, the CTN-0124 study team developed a 9-month engineering systems analysis, a problem-solving approach that breaks a system into its individual parts, analyzes how well those parts work together to accomplish their purpose, and creates an aspirational design for the future. To perform this analysis, the study team, made up of 5 systems analysis (3 from health care and 2 from…

Here are the latest items added to the CTN Dissemination Library for June – July 2024 (this post will be updated as new items come in): Extended-Release 7-Day Injectable Buprenorphine for Patients With Minimal to Mild Opioid Withdrawal. D’Onofrio G, et al. JAMA Network Open 2024;7(7):e2420702. The Potential Impact of Clinical Decision Support on Nonwaivered Primary Care Clinicians’ Prescribing of Buprenorphine. Olson AW, et al. Health Affairs Scholar 2023;1(4):qxad051. CTN-0076-Ot Barriers and Facilitators to Using a Clinical Decision Support Tool for Opioid Use Disorder in Primary Care: Insights from Clinicians and Clinic Leaders. Hooker SA, et al. Journal of the American Board of Family Medicine 2024 (in press). CTN-0076-Ot Assessing Substance Use Disorder Symptoms with a Checklist among Primary Care Patients with Opioid Use Disorder and/or Long-Term Opioid Treatment: An Observational Study. Williams EC, et al. Journal of General Internal Medicine 2024 (in press). CTN-0113 Predictability of Buprenorphine-Naloxone Treatment Retention: A Multi-Site Analysis Combining Electronic Health Records and Machine Learning. Haredasht FN, et al. Addiction 2024 (in press). CTN-0136 Predictors of Urine Toxicology and Other Biologic Specimen Missingness in Randomized Trials of Substance Use Disorders. Kelley AT, et al. Drug and Alcohol Dependence 2024;261:111368. (multiple protocols)

Here are the latest items added to the CTN Dissemination Library for May – June 2024 (this post will be updated as new items come in): “To prescribe or not to prescribe, that is the question”: Perspectives on opioid prescribing for chronic, cancer-related pain from clinicians who treat pain in survivorship. Bulls HW, et al. Cancer. 2024 Apr 3. doi: 10.1002/cncr.35299. PMID: 38567685. CTN-0115 Substance Use Among Black Adolescents – Maximizing Strengths and Overcoming Barriers in Substance Use Prevention. Aneni K. Youth Special Interest Group (SIG) webinar, May 2024. Wiidookaage’win: Beta-test of a Facebook Group Intervention for Native Women to Support Opioid Use Recovery. Roche AI, et al. Journal of Substance Use and Addiction Treatment 2024;163:209396. Discontinuation of Medication Treatment for Opioid Use Disorder After a Successful Course: The Discontinutaion Phase of the CTN-0100 (RDD) Trial. Discontinuation of Medication Treatment for Opioid Use Disorder After a Successful Course: The Discontinutaion Phase of the CTN-0100 (RDD) Trial. Shulman M, et al. Contemporary Clinical Trials 2024;142:107543. CTN-0100 Addiction Medicine Treatment Utilization by Race/Ethnicity Among Adolescents with Substance Use Problem Before Versus During the COVID-19 Pandemic. Palzes VA, et al. Journal of Adolescent Health 2024;74(6):1260-1263. CTN-0117 Overall and Telehealth Addiction Treatment Utilization by Age, Race, Ethnicity, and Socioeconomic Status in California After COVID-19 Policy Changes. Palzes VA, et al. JAMA Health Forum 2023;4(5):e231018. CTN-0117

The primary outcomes article for CTN-0097, Surmounting Withdrawal to Initiate Fast Treatment with Naltrexone (SWIFT): Improving the Real-World Effectiveness of Injection Naltrexone for Opioid Use Disorder (NIH HEAL Initiative), is now available! Published in JAMA Network Open, the findings from the study suggest that starting people with opioid use disorder (OUD) on extended-release injectable naltrexone (XR-naltrexone) within 5-7 days of seeking treatment is more effective than the standard treatment method of starting within 10-15 days, but requires closer medical supervision. This rapid treatment protocol could make XR-naltrexone more viable as a treatment option for OUD, as the longer waiting period was a significant barrier to implementation of XR-naltrexone for many patients. Read the JAMA Network Open paper | Read the NIDA News Release about it

ATTENTION! The new CTN Directory is here! Published in April 2024, it has updated contact information for members of all 16 nodes, the Clinical Coordinating Center, and the Data and Statistics Center. You can find a link to it right on the CTN Dissemination Library’s home page as well as RIGHT HERE. Here are the latest items added to the CTN Dissemination Library for April – May 2024 (this post will be updated as new items come in): Rapid Initiation of Injection Naltrexone for Opioid Use Disorder: A Stepped-Wedge Cluster Randomized Clinical Trial. Shulman M, et al. JAMA Network Open 2024;7(5):e249744. Primary Outcomes Article for CTN-0097 Empirically Contrasting Urine Drug Screening-Based Opioid Use Disorder Treatment Outcome Definitions. Brandt L, et al. Addiction 2024 (in press). CTN-0094 Program Director Reports of COVID-19 Lockdown-Driven Service Changes in Community-Based STI Clinics and Syringe Services Programs in the Southeastern U.S. Hatch MA, et al. AIDS Education and Prevention 2024;36(2):129-140.

ATTENTION! The new CTN Directory is here! Published in April 2024, it has updated contact information for members of all 16 nodes, the Clinical Coordinating Center, and the Data and Statistics Center. You can find a link to it right on the CTN Dissemination Library’s home page as well as RIGHT HERE. Here are the latest items added to the CTN Dissemination Library for March – April 2024 (this post will be updated as new items come in):  Exemplar Hospital Initiation Trial to Enhance Treatment Engagement (EXHIT ENTRE): Protocol for CTN-0098B A Randomized Implementation Study to Support Hospitals in Caring for Patients with Opioid Use Disorder. Bart G, et al. Addiction Science & Clinical Practice 2024;19:29. National Institute on Drug Abuse Clinical Trials Network Meeting Report: Managing Patients Exposed to Xylazine-Adulterated Opioids in Emergency, Hospital and Addiction Care Settings. Perrone J, et al. Annals of Emergency Medicine 2024 (in press). Medication-Based Treatment Among Rural, Primary Care Patients Diagnosed with Opioid Use Disorder and Alcohol Use Disorder. Kan E, et al. Journal of Substance Use and Addiction Treatment 2024 (in press). CTN-0102 Implementing a Pharmacist-Integrated Collaborative Model of Medication Treatment for Opioid Use Disorder in Primary Care: Study Design and Methodological Considerations. McLeman B, et al. Addiction Science & Clinical Practice 2024;19:18. CTN-0116 Comparing Cannabis Use for Pain to Use for Other Reasons in Primary Care Patients. Ford MA, et al. Journal of the American Board of Family Medicine 2023;36(6):996-1007.

Here are the latest items added to the CTN Dissemination Library for February – March 2024 (this post will be updated as new items come in):  Protocol for Harmonization of Randomized Trials Testing the Addition of Behavioral Therapy to Buprenorphine for Opioid Use Disorder. McHugh RK, et al. Drug and Alcohol Dependence Reports 2024 (in press). (CTN-0030) PrEP for People Who Use Opioids: A NIDA Clinical Trials Network Survey Study in Southern U.S. Cities Where HIV Incidence is High. Hatch M, et al. Drug and Alcohol Dependence 2024;257:111133. (Primary outcomes for CTN-0082) Referral of Patients from Rural Primary Care Clinics to Telemedicine Vendors for Opioid Use Disorder Treatment: A Mixed-Methods Study. Lin C, et al. Journal of Telemedicine and Telecare 2024 (in press). (CTN-0102) Medication Treatment for Opioid Use Disorder Among Rural Primary Care Patients. Hser Y, et al. Journal of Rural Health 2024;40(1):195-199. (CTN-0102) Subthreshold Opioid Use Disorder Prevention (STOP) Trial: A Cluster Randomized Clinical Trial: Study Design and Methods. Liebschutz JM, et al. Addiction Science & Clinical Practice 2023;18(1):70. (CTN-0101) Posted on February 20, 2024

Here are the latest items added to the CTN Dissemination Library for January – February 2024 (this post will be updated as new items come in): 

This webinar from the CTN Clinical Coordinating Center (CCC) completes a broad overview of the infrastructure of the NIDA CTN, including how Local Nodes interact with the sponsor as well as study sites. A summary of available resources for new nodes and research sites was provided for a variety of Local Node activities. Lastly, best practices were reviewed, as well as ways to avoid common mistakes. Facilitator: Lynn Kunkel, MS, CCRP Presenter: Frankie Kropp, MS, LICDCPresented on February 7, 2024 Watch the recording here | Find more CTN webinars here Posted on February 15, 2024