The primary outcomes article for CTN-0097, Surmounting Withdrawal to Initiate Fast Treatment with Naltrexone (SWIFT): Improving the Real-World Effectiveness of Injection Naltrexone for Opioid Use Disorder (NIH HEAL Initiative), is now available! Published in JAMA Network Open, the findings from the study suggest that starting people with opioid use disorder (OUD) on extended-release injectable naltrexone (XR-naltrexone) within 5-7 days of seeking treatment is more effective than the standard treatment method of starting within 10-15 days, but requires closer medical supervision. This rapid treatment protocol could make XR-naltrexone more viable as a treatment option for OUD, as the longer waiting period was a significant barrier to implementation of XR-naltrexone for many patients. Read the JAMA Network Open paper | Read the NIDA News Release about it

ATTENTION! The new CTN Directory is here! Published in April 2024, it has updated contact information for members of all 16 nodes, the Clinical Coordinating Center, and the Data and Statistics Center. You can find a link to it right on the CTN Dissemination Library’s home page as well as RIGHT HERE. Here are the latest items added to the CTN Dissemination Library for April – May 2024 (this post will be updated as new items come in): Rapid Initiation of Injection Naltrexone for Opioid Use Disorder: A Stepped-Wedge Cluster Randomized Clinical Trial. Shulman M, et al. JAMA Network Open 2024;7(5):e249744. Primary Outcomes Article for CTN-0097 Empirically Contrasting Urine Drug Screening-Based Opioid Use Disorder Treatment Outcome Definitions. Brandt L, et al. Addiction 2024 (in press). CTN-0094 Program Director Reports of COVID-19 Lockdown-Driven Service Changes in Community-Based STI Clinics and Syringe Services Programs in the Southeastern U.S. Hatch MA, et al. AIDS Education and Prevention 2024;36(2):129-140.

ATTENTION! The new CTN Directory is here! Published in April 2024, it has updated contact information for members of all 16 nodes, the Clinical Coordinating Center, and the Data and Statistics Center. You can find a link to it right on the CTN Dissemination Library’s home page as well as RIGHT HERE. Here are the latest items added to the CTN Dissemination Library for March – April 2024 (this post will be updated as new items come in):  Exemplar Hospital Initiation Trial to Enhance Treatment Engagement (EXHIT ENTRE): Protocol for CTN-0098B A Randomized Implementation Study to Support Hospitals in Caring for Patients with Opioid Use Disorder. Bart G, et al. Addiction Science & Clinical Practice 2024;19:29. National Institute on Drug Abuse Clinical Trials Network Meeting Report: Managing Patients Exposed to Xylazine-Adulterated Opioids in Emergency, Hospital and Addiction Care Settings. Perrone J, et al. Annals of Emergency Medicine 2024 (in press). Medication-Based Treatment Among Rural, Primary Care Patients Diagnosed with Opioid Use Disorder and Alcohol Use Disorder. Kan E, et al. Journal of Substance Use and Addiction Treatment 2024 (in press). CTN-0102 Implementing a Pharmacist-Integrated Collaborative Model of Medication Treatment for Opioid Use Disorder in Primary Care: Study Design and Methodological Considerations. McLeman B, et al. Addiction Science & Clinical Practice 2024;19:18. CTN-0116 Comparing Cannabis Use for Pain to Use for Other Reasons in Primary Care Patients. Ford MA, et al. Journal of the American Board of Family Medicine 2023;36(6):996-1007.

Here are the latest items added to the CTN Dissemination Library for February – March 2024 (this post will be updated as new items come in):  Protocol for Harmonization of Randomized Trials Testing the Addition of Behavioral Therapy to Buprenorphine for Opioid Use Disorder. McHugh RK, et al. Drug and Alcohol Dependence Reports 2024 (in press). (CTN-0030) PrEP for People Who Use Opioids: A NIDA Clinical Trials Network Survey Study in Southern U.S. Cities Where HIV Incidence is High. Hatch M, et al. Drug and Alcohol Dependence 2024;257:111133. (Primary outcomes for CTN-0082) Referral of Patients from Rural Primary Care Clinics to Telemedicine Vendors for Opioid Use Disorder Treatment: A Mixed-Methods Study. Lin C, et al. Journal of Telemedicine and Telecare 2024 (in press). (CTN-0102) Medication Treatment for Opioid Use Disorder Among Rural Primary Care Patients. Hser Y, et al. Journal of Rural Health 2024;40(1):195-199. (CTN-0102) Subthreshold Opioid Use Disorder Prevention (STOP) Trial: A Cluster Randomized Clinical Trial: Study Design and Methods. Liebschutz JM, et al. Addiction Science & Clinical Practice 2023;18(1):70. (CTN-0101) Posted on February 20, 2024

Here are the latest items added to the CTN Dissemination Library for January – February 2024 (this post will be updated as new items come in): 

This webinar from the CTN Clinical Coordinating Center (CCC) completes a broad overview of the infrastructure of the NIDA CTN, including how Local Nodes interact with the sponsor as well as study sites. A summary of available resources for new nodes and research sites was provided for a variety of Local Node activities. Lastly, best practices were reviewed, as well as ways to avoid common mistakes. Facilitator: Lynn Kunkel, MS, CCRP Presenter: Frankie Kropp, MS, LICDCPresented on February 7, 2024 Watch the recording here | Find more CTN webinars here Posted on February 15, 2024

Here are the latest items added to the CTN Dissemination Library for December 2023 – January 2024 (this post will be updated as new items come in): Webinars Alliances to Disseminate Addiction Prevention and Treatment (ADAPT): A Learning Health System to Improve Evidence-based Practices and Treatment, presented by Matt Aalsma, PhD. (CTN Translation & Implementation SIG webinar, 2023) Human-Centered Implementation Science? Improving the Design and Adaptation of Our Best Interventions and Strategies, presented by Aaron Lyon, PhD. (CTN Translation & Implementation SIG webinar, June 2023) When to Start Caring About Implementability: Pretty Much Now, presented by Geoffrey Curran, PhD. (CTN Translation & Implementation SIG webinar, May 2023) Journal Articles Co-occurring Substance Use Disorders Among Patients with Opioid Use Disorder in Rural Primary Care Clinics. Zhu Y, et al. Journal of Substance Use & Addiction Treatment 2023 (in press). CTN-0102 Lessons Learned and Future Directions: A Scoping Review of American Indian and Alaska Native Participants in the National Drug Abuse Treatment Clinical Trials Network. Crouch MC, et al. Journal of Substance Use and Addiction Treatment 2023;153:209081. Updated on 1/10/2024

Here are the latest items added to the CTN Dissemination Library for October-November 2023 (this post will be updated as new items come in): Prescription Opioid Dose Reductions and Potential Adverse Events: A Multi-Site Observational Cohort Study in Diverse US Health Systems. Metz VE, et al. Journal of General Internal Medicine 2023 (in press). CTN-0084 Nurse Care Management for Opioid Use Disorder Treatment: The PROUD Cluster Randomized Clinical Trial. Wartko PD, et al. JAMA Internal Medicine 2023:3235701 (in press). CTN-0074 Assessment of Screening Tools to Identify Substance Use Disorders Among Adolescents. Levy S, et al. JAMA Network Open 2023;6(5):e2314422. Research Priorities for Expansion of Opioid Use Disorder Treatment in the Community Pharmacy. Jarrett JB, et al. Substance Abuse 2023;44(4):264-276. Treatment Initiation, Substance Use Trajectories, and the Social Determinants of Health in Persons Living With HIV Seeking Medication for Opioid Use Disorder. Cook RR, et al. Substance Abuse 2023 (in press). CTN-0067 Stakeholder Perspectives on a Telemedicine Referral and Coordination Model to Expand Medication Treatment for Opioid Use Disorder in Rural Primary Care Clinics. Ober AJ, et al. Journal of Substance Use & Addiction Treatment 2024;156:209194. Prevalence of Cannabis Use Disorder and Reasons for Use Among Adults in a US State Where Recreational Cannabis Use is Legal. Lapham GT, et al. JAMA Network Open 2023;6(8):e2328934. CTN-0077-Ot

Here are the latest items added to the CTN Dissemination Library for September-October 2023 (this post will be updated as new items come in): Potential Effect of Antidepressants on Remission from Cocaine Use Disorder — A Nationwide Matched Retrospective Cohort Study. Gao Z, et al. Drug & Alcohol Dependence 2023;251:110958. CTN-0114 Individual-Level Risk Prediction of Return to Use During Opioid Use Disorder Treatment. Luo SX, et al. JAMA Psychiatry 2023 (in press). CTN-0027, CTN-0030, CTN-0051 Training Opportunities to Leverage the CTN Network. Crump A. Webinar presented at the NIDA Steering Committee Meeting, September 18, 2023. Implementation of Substance Use Screening in Rural Federally-Qualified Health Center Clinics Identified High Rates of Unhealthy Alcohol and Cannabis Use Among Adult Primary Care Patients. McNeely J, et al. Addiction Science & Clinical Practice 2023;18(1):56. CTN-0062 Identifying Patients with Opioid Use Disorder Using International Classification of Diseases (ICD) Codes: Challenges and Opportunities. Osterhage KP, et al. Addiction 2023 (in press). CTN-0102 Associations Between Stimulant Use and Return to Illicit Opioid Use Following Initiation onto Medication for Opioid Use Disorder. Foot C, et al. Addiction 2023 (in press). CTN-0051, CTN-0067 Posted on September 20, 2023; updated September 28, 2023

This presentation for the NIDA CTN Steering Committee Meeting held on September 18, 2023, featured Aria Crump, ScD, Deputy Director of the NIDA Office of Research, Training, Diversity and Disparities and Director of the NIDA Office of Diversity and Disparities. This 35-minute presentation provides information about different types of funding available through NIDA, focusing on career development and workforce diversity. Dr. Crump reviewed a range of different types of NIDA awards, including R, T, and K awards, HEAL Initiative awards, and unique programs like NIDA’s Loan Repayment Program, which helps early career investigators, especially those from underrepresented backgrounds, repay their student loans. She also demonstrated how to use the NIH RePORTER to find information about active awards and talked about NIH’s ongoing commitment to diversity and dedication to supporting early career investigators and other scientists from a range of backgrounds and specialties. Watch the recording here!